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Through the 2017 regular season, the two teams have played 711 games. The Houston Astros have 378 wins and 333 losses against the Chicago Cubs.
Through the 2008 season, the fewest losses by an MLB team in a regular season is 36 by the 1906 Chicago Cubs. The 1906 Cubs are tied, with the 2001 Seattle Mariners, for most wins by a team in an MLB regular season with 116.
The Cubs (1906) and Mariners (2001) who won 116 games in one season.
The 2001 Seattle Mariners and 1906 Chicago Cubs have that record with 116 wins in an MLB season.This was actually done twice. First by the Chicago Cubs in 1906 with 116 wins, and then the Seattle Mariners did the same in 2001. Unlike the Mariners the Cubs had a 152 game season, so they could have achieved more wins because the Mariners season was 162 games long.
NO Ironically, the Cubs signed Soriano this past off-season (2007) and Sosa signed with the Rangers, but no trade was involved.