"Interleague" games between AL & NL occur every season. It varies since all teams have unique schedules, there's no finite number to be played. Normally, most interleague games are clustered towards midseason-for logistic reasons. All teams play @least one series against opposing league, but routinely vs a few teams. Matchups seem randomly set, but most likely there's a format & rotating schedule ensuring all teams eventually meet eachother. In the spirit of tradition & history, priority for regional rivalries is given, i.e. "Bay Bridge Series" between AL's Oakland Athletics & NL's San Francisco Giants. These matchups usually consist of 2, 3 or even 4 games per series played at each teams ballpark, with weeks or even months passing between both series.
To answer the question: No less than 3 games, no more than 16, per team per season.
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The American Football League first played games in 1960.
The American League began as a minor league called the Western League whose first season was 1894. The named was changed to American League for the 1900 season and the AL declared itself a major league for the 1901 season.
Philadelphia had two Major League teams in 1909. The Athletics played in the American League and the Phillies played in the National League.
No, but there were three. Between 1903-1957, the New York Yankees played in the American League and the Brooklyn Dodgers and the New York Giants played in the National League.
Red Sox and Yankees are in the same league (American) and so they can not meet in the World Series since the World Series is played between the winners of the American League and National League of the Major Baseball League