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The highest scoring game in Major League Baseball history was played between the Chicago Cubs and the Philadelphia Phillies in 1922. The two teams combined for 49 runs with the Cubs beating the Phillies by a score of 26-23.

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Q: Highest MLB score
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On June 8, 1950, the St. Louis Browns battled against the Boston Red Sox and lost 29-4. However, on August 25, 1922, the Chicago Cubs just beat the Philadelphia Phillies in a 26-23 game that, together, added up to 49 runs, being the largest MLB score ever.


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