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Yes ... on July 25, 1956 against the Cubs at Forbes Field in Pittsburgh. It came with no outs in the bottom of the 9th inning and gave the Pirates a 9-8 win. To this day it is the only walkoff inside the park grand slam in MLB history.
Fred Lynn hit the first Grand Slam in an All-Star Game in 1983, which was played at Comiskey Park on the 50th Anniversary of the first Home Run to be hit in an All-Star Game. That was hit by Babe Ruth and was also hit at Comiskey Park in 1933, the first All-Star Game in history.
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Unfortunately, the most recent data I could find was for the 2008 MLB season. In 2008, 124 grand slams were hit (72 in the AL and 52 in the NL) in 2428 total games for an average of 1 grand slam every 19.58 games. The most grand slams hit in an MLB season is 176 (89 in the AL and 87 in the NL) in 2429 games in the 2000 season for an average of 1 grand slam every 13.80 games.
Lou Gehrig hit 23 career grand slam home runs, the most by any player in Major League Baseball history.