Yes, Pujols hit one i dont know about anyone else though
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The first home run in Mets regular season history was hit by Gil Hodges in the 4th inning of a game against the St. Louis Cardinals on April 11, 1962. Hodges hit the home run off of Larry Jackson.
In 2011, the Minnesota Twins hit 103 home runs.
In 2010, Robinson Cano hit 29 home runs.
Rogers Hornsby hit 42 home runs in 1922.
Both Albert Pujols (in April 2006) and Alex Rodriguez (in April 2007) hit 14 home runs during the fourth month.