Yes. On September 28, 2000, the Pittsburgh Pirates defeated the Houston Astros, 3-2.
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Rich Loiselle debuted on September 7, 1996, playing for the Pittsburgh Pirates at Three Rivers Stadium; he played his final game on October 6, 2001, playing for the Pittsburgh Pirates at PNC Park.
Wil Cordero played in just one game at designated hitter for the Pittsburgh Pirates in 2000 and did not start. , equivalent to 0 errors per game (estimate based on total games played in).
Kevin Young played in just one game at designated hitter for the Pittsburgh Pirates in 2000 and did not start. , equivalent to 0 errors per game (estimate based on total games played in).
Francisco Cordova debuted on April 2, 1996, playing for the Pittsburgh Pirates at Three Rivers Stadium; he played his final game on August 8, 2000, playing for the Pittsburgh Pirates at Three Rivers Stadium.
Jason Grilli debuted on May 11, 2000, playing for the Florida Marlins at Pro Player Stadium; he played his final game on September 27, 2013, playing for the Pittsburgh Pirates at PNC Park.