That's hard to answer. I've picked first and I've picked last (12th - in a 12-team league) and its always fun to get that first pick but its no guarantee that you'll win a championship.
The last time I won my league (2003) I had the top pick but my first pick didn't win the league for me. In fact, I think my second pick (24th) won me the league. I picked Jamal Lewis, RB Ravens (at that time) who was coming off a knee injury. Lewis had a monster year rushing for more than 2,000 yards and leading the league in rushing. Also, I grabbed Tory Holt who had a break-out season and became the top target in the high-flying St. Louis Rams offense.
Have fun and realize that any pick has the potential to win you the next league championship.
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