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It would depend upon who was addressed, and whether it is more than one person. The singular and plural formal you as compared to the singular and plural familiar would be:

'What (do) you mean?' = '¿Qué quiere / quieren / quieres / queréis decir?'

ANALYSE:

Usted (formal singular, both genders)

Ustedes (formal plural, both genders)

(informal singular, both genders)

Vosotros, as (informal plural, masculine / feminine)

Qué --- What?

Que --- That, which, who (relative clause)

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11y ago

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