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The 2 Matts. Matt Hughes beat him via armbar submission in UFC 50 on October 2004. A defeat which GSP avenged by getting a TKO on Hughes in UFC 65 on November 2006. His next fight would be his second loss, this time at the hands (TKO) of Matt Serra in UFC 69 (a fight which I had the pleasure of watching live and in person) on April 2007. St-Pierre would also avenge this loss via his own TKO in UFC 83 a year later.
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