4.45 Sec.
According to http://football.about.com/od/nationalfootballleague/p/santonioholmes.htm 4.45 Sec.
According to http://football.about.com/od/nationalfootballleague/p/santonioholmes.htm
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I know in the N.F.L. superstars competition he once ran the hundred yard dash in 9.3 seconds. That would easily put him in the low 4 second range.