The first American World Chess Champion was Robert Fisher.
Bobby Fischer became the first American World Chess champion in 1975.
1869 was the first intercollegiate football game.
Alpha Phi Alpha was the first African-American intercollegiate Greek organization. It was established at Cornell in 1905-6.
the first first intercollegiate soccer game was held in new yersey.
First tournament was in New York, 1843.
The first intercollegiate sporting event took place on August 3, 1852. It was a rowing race between Harvard and Yale.
No American has won the Champions League to my knowledge.