Lou Gerhig 49.
The Chicago White Sox led the majors in Home Runs with 235.
In 2009 Albert Pujols led the National League with 47 home runs. Carlos Pena, and Mark Teixeira led the Amercan League with 39.
Barry Bonds and Juan Gonzalez each hit 46
Albert Belle of the Cleveland Indians hit 50 home runs in 1995 to lead MLB.
Duke Snider of the Brooklyn/Los Angeles Dodgers with 326.
Albert Pujols led the MLB with 47 home runs in 2009. He was followed by Prince Fielder (46) and Ryan Howard (45)
In 1962, Willie Mays led Major League baseball with 49 home runs. Harmon Killebrew was second, with 48.
In 1973 Willie Stargell led the National League in home runs with 44, and Reggie Jackson led the American Legue with 32.
Sammy Sosa led MLB in home runs in 2000 with 50.
16, all by National League pitchers. Yovani Gallardo of the Milwaukee Brewers led all pitchers in home runs with 4.