Most Interceptions ThrownGeorge Blanda (Houston Oilers '62) threw the most interceptions in one season.
Rashean Mathis had 31 interceptions for Bethune-Cookman from 1999 to 2003.
rod Wilson holds the nfl record for interceptions retuned for touchdowns with 12.
Peyton Manning with 28.
Night Train Layne
Rod Woodson with 12.
The quarterback who has thrown the most interceptions is Brett Favre, who through the 2010 season has thrown 336 career interceptions. The record for most interceptions by a defensive player in a career is held by Paul Krause, who intercepted 81 career passes.