The quarterback who has thrown the most interceptions is Brett Favre, who through the 2010 season has thrown 336 career interceptions. The record for most interceptions by a defensive player in a career is held by Paul Krause, who intercepted 81 career passes.
Defensive back Mel Blount (1970-1983) is the Steelers' all-time leader with 57 interceptions.
Through the 2009 season, that is Brett Favre with 317 career interceptions.
Paul Krause who played for the Minnesota Vikings. He had 81 interceptions for his career.
Raiders defensive back Charles Woodson holds the career NFL record for the most defensive touchdowns. Charles Woodson has 13 defensive touchdowns.
The career interception record is held by Paul Krause with 81 interceptions. The single-season record is held by Dick "Night Train" Lane with 14 interceptions. The most interceptions caught in a game is 4 by 20 players.
Jim Hardy-8... He played for the Chicago Cardinals and this record was broken in 1950
Baltimore LB Don Shinnick holds the record all-time record for linebackers with 37 career interceptions. Shinnick played from 1957-1969. Amongst active players, Ray Lewis leads the league with 29 career interceptions. Source: Playerfilter
Career interceptions thrown, is Terry Bradshaw with 210. The single season Steelers record is Jim Finks in 1955 with 26 interceptions thrown.
The Brown University record for career interceptions is 14 and is held jointly by Greg Parker and Joe Paterno.