Wilt Chamberlain holds that record.
Mario Lemieux, Simon Gagne and Braydon Schenn have the record for most scored by a Canadian in one game (4)...unable to find any records of most goals scored by any player in a single game, so I think this is the record
The record for most runs scored by a player in a single game is 7, set by Gut Hecker of the American Association's Louiville Colonels on August 15, 1886
Wilt Chamberlain scored an NBA record 100 points against the Knicks on March 2, 1962. See http://www.answers.com/topic/wilt-chamberlain-s-100-point-game.
Career Record: Emmitt Smith of the Dallas Cowboys. He has five rushing touchdowns scored over three games. Single Game Record: Terrell Davis of the Denver Broncos scored three rushing touchdowns in a single game.
College Basketball 258 scored by Troy University