Barry Bonds hit the most home runs in MLB history, with 762.
Barry Bonds.
Barry Bonds holds the major league records for career home runs (762) and for a single season (73 in 2001).
Through the 2008 season, Manny Ramirez has hit the most home runs in MLB playoff history with 28.
The Yankee's have (to present date) the most 200+ home run seasons in baseball history with 10.
Hank Aaron has hit the second most runs in the MLB history with 755 in his 23 seasons with the Milwaukee/Atlanta Braves and Milwaukee Brewers.
Barry Bonds 's 762 Home runs put him up on top for Homers.
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Lou Gehrig hit 23 career grand slam home runs, the most by any player in Major League Baseball history.
4 is the record, and quite a few guys have done it.
In the world of professional baseball, the player that hit the most home runs was Sadaharu Oh of the Nippon Professional League in Japan who hit 868 home runs in his career that spanned 1959-1980. In Major League baseball, Barry Bonds hit the most home runs with 762.
The record for the most home runs in baseball history is held by Barry Bonds, who hit a total of 762 home runs throughout his career. He surpassed Hank Aaron's previous record of 755 home runs in 2007. Bonds achieved this milestone despite controversies surrounding his alleged use of performance-enhancing drugs.