March 30th, 2000 found the Yankees at Enron Field in Houston, set to play the inaugural exhibition game at the new retractable-roof dome against the Astros. When the Astrodome first opened in 1965, the Astros had also faced the Yankees for an exhibition game to open their new stadium. Back on April 9, 1965, in that game, Mickey Mantle became the first player ever to hit a home run in the Dome. On March 30,2000, Ricky Ledee pinch hitting for Clemens, promptly hit the first home run to leave Enron Field.
The first home run hit at Jacobs Field was April 4, 1994 by Eric Anthony of the Settle Mariners.
Joe Girardi in 1998
The first home run was hit on 4/26/1912 by Hugh Bradley over the Green Monster in left field.
The players with the most home runs at Minute Maid park (including Enron Field) through 2008 season; Lance Berkman, 128 Jeff Bagwell, 108 Craig Biggio, 79 Morgan Ensberg, 65
Richie Sexson hit a 503 foot home run to center field in 2004
Ernie Banks hit the most home runs at Wrigley Field with 290. Coming in second is Billy Williams with 241. The first home run at Wrigley Field was by Art Wilson of the Chicago Whales in a Federal League game on April 23, 1914.
Russ Davis of the Mariners hit the first home run Safeco Field history in the 5th inning of the game against the San Diego Padres on July 17, 1999.
Manny Alexander. Shortstop Alexander hit the HR off of John Smoltz in the 8th inning of the first game the Mets played at Turner Field, July 10, 1997.
That was Cecil Fielder of the Detroit Tigers in the 3rd inning of the first regular season game played in U.S. Cellular Field on April 18, 1991.
Wally Post of the Cincinnati Reds, 1962, straight away center field.
Suck it Trebek
That was Michael Tucker in the 3rd inning of the first game played at Turner Field, April 4, 1997. The Braves won 5-4.
Daniel Sepic of Pennsylvania hit the first ever home run.
Ron Santo hit his first Major League home run on July 3, 1960, at Wrigley Field, Chicago, off Reds pitcher Jim O'Toole.
Ariel Ceballos ; 326 ft shot to left field
Comerica Park, home of the Detroit Tigers.
He hit no Home Runs in his first year which was 1914
Babe Ruth hit his first home run in 1915. As he was born in 1895, he would be 20 years old when he hit his first home run.