Manny Ramirez with 23 (up till 10/7/09)
Barry Bonds has the most career home runs with 762.
Babe Ruth has the most career home runs as a Yankee with 659.
Rafael Palmeiro with 569 career home runs.
Most Career Home Runs: Through October 22, 2016, Barry Bonds has the most career home runs with 762. Hank Aaron previously held the record with 755 home runs. Third on the career home run list is Babe Ruth with 714, and Alex Rodriguez, fourth with 696. Fifth on the list is Willie Mays with 660 home runs.
Mickey Mantle has the most career World Series home runs with 18.
Barry Bonds holds the major league records for most home runs in a career (762) and most home runs in a season (73).
Through the 2008 season, Manny Ramirez has hit the most home runs in MLB playoff history with 28.
Slugger Barry Bonds holds the record for the most home runs in a career. In the course of his career, he blasted 762 out of the park.
most Career Postseason Home RunsAs of the 2009 Season, Manny Ramirez holds the record for most career postseason home runs with 29. Bernie Williams is second with 22, and Derek Jeter is third with 20. Reggie Jackson and Mickey Mantle are ties for fourth with 18 home runs each but Mickey Mantle hit his 18 home runs in the World Series as there were no playoff games in his day.
Babe Ruth is third on the all time home run list with 714 home runs.
Barry Bonds, with 762 home runs.
He holds the major league records for most home runs in a career (762) and most home runs in a season (73).