I'm pretty sure the most home runs against the Yankees was Manny Ramirez, but the most hits might be Ted Williams.
Steve Peek debuted on April 16, 1941, playing for the New York Yankees at Yankee Stadium I; he played his final game on September 6, 1941, playing for the New York Yankees at Yankee Stadium I.
Ivy Andrews debuted on August 15, 1931, playing for the New York Yankees at Yankee Stadium I; he played his final game on September 28, 1938, playing for the New York Yankees at Yankee Stadium I.
Rugger Ardizoia debuted on April 30, 1947, playing for the New York Yankees at Yankee Stadium I; he played his final game on April 30, 1947, playing for the New York Yankees at Yankee Stadium I.
Honey Barnes debuted on April 20, 1926, playing for the New York Yankees at Yankee Stadium I; he played his final game on April 20, 1926, playing for the New York Yankees at Yankee Stadium I.
Rich Beck debuted on September 14, 1965, playing for the New York Yankees at Yankee Stadium I; he played his final game on September 28, 1965, playing for the New York Yankees at Yankee Stadium I.
Bill Bevens debuted on May 12, 1944, playing for the New York Yankees at Yankee Stadium I; he played his final game on September 27, 1947, playing for the New York Yankees at Yankee Stadium I.
Norm Branch debuted on May 5, 1941, playing for the New York Yankees at Yankee Stadium I; he played his final game on August 20, 1942, playing for the New York Yankees at Yankee Stadium I.
Jim Brenneman debuted on July 9, 1965, playing for the New York Yankees at Yankee Stadium I; he played his final game on July 23, 1965, playing for the New York Yankees at Yankee Stadium I.
Marv Breuer debuted on May 4, 1939, playing for the New York Yankees at Yankee Stadium I; he played his final game on August 28, 1943, playing for the New York Yankees at Yankee Stadium I.
Tommy Byrne debuted on April 27, 1943, playing for the New York Yankees at Yankee Stadium I; he played his final game on September 21, 1957, playing for the New York Yankees at Yankee Stadium I.
Spud Chandler debuted on May 6, 1937, playing for the New York Yankees at Yankee Stadium I; he played his final game on September 26, 1947, playing for the New York Yankees at Yankee Stadium I.
Jack Reed debuted on April 23, 1961, playing for the New York Yankees at Yankee Stadium I; he played his final game on September 28, 1963, playing for the New York Yankees at Yankee Stadium I.