Pete Rose with 3,562 games played.
Gordie Howe holds the record for most career games played.
The Major League Baseball player who holds the career record for the most games played is Pete Rose who has played in 3,562 games, the player who has grounded into the double plays in their career is Cal Ripken, Jr. who has grounded into 350 double plays and the player who holds the career record with having the most assists is Elvis Andrus who has recorded 516 in his career.
Derek Jeter holds the record for most career games played in the postseason with 138.
Babe Ruth with 72
271 by Wilt Chamberlain
A very talented famous baseball player who played his entire career with the Baltimore Orioles, broke Lou Gehrig's record for consecutive games played, and was elected to baseball's Hall of Fame.
Carl Yastrzemski holds the record for most career games played with the Boston Red Sox with 3,308.
Pete Rose holds the record for most career multi-hit games doing it 1,225 times in his career.
Pete Rose, who played in 3,562 games in his career.