Mickey Mantle with 266 HRs.
Roger Maris in 61 I believe.
Mariano Rivera (230 at the original Yankee Stadium, which is not only the most at Yankee Stadium, but the most at ANY ballpark).
Manny Ramirez did when he was a Red Sox player.
Mariano Rivera He has the most saves at Old Yankee Stadium (230), and he has a good chance to have the most at New Yankee Stadium.
Goose Goslin holds the record for most home runs hit at Yankee Stadium by an opposing player (32).
Derek Jeter with 1,274 hits.
in 2009 New Yankee stadium