Between 2007-2010, that is the Detroit Lions with 49 losses.
The team with the most losses in NFL history is the Tampa Bay Buccaneers.
the vikings
Detroit Lions
The Tampa Bay Buccaneers hold the title for being the NFL team with the most losses in history.
lions
the 49ers
Vikings
Arizona Cardinals- 680 losses
I don't know and don't care.
San Francisco 49ers with 14.The Cleveland Browns and Miami Dolphins had the second most losses with 12.
The St. Louis Rams with 15 losses.