Emmitt Smith,with 18,355 rushing yards, currently holds the record for the highest rushing yards in the game.
Emmitt Smith holds the record for most rushing yards in a career with 18,355 yards. Eric Dickerson holds the record for most rushing yards in a season with 2,105 yards. Adrian Peterson holds the record for most rushing yards in a single game with 296 yards.
Steve sleton holds the record with 654 rushing yards
As of 2007, Emmitt Smith holds the record for 18,400 rushing yards. He also holds the record for the most rushing touchdowns with 164. Second place is Ladainian Tomlinson with about 120.
Ron Dayne currently hold the record for the most rushing yards in college
Michael Vick has the most rushing yards by a quarterback with 5,139 yards.
Eddie George holds the record with 314 yards against Illinois on Nov. 11, 1995.
In 1992, Barry Foster set the Steelers record for most rushing yards in a season with 1,690.
Timmy Smith (204 Rushing yards).