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Opening day for the Red Sox was April 13, 2012.

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Q: When was the Red Sox opening day in 2012?
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What was the original opening day for the Red Sox in 1912?

Opening day for the Red Sox was April 11 against the Highlanders (Yankees) at Hilltop Park in New York. The Red Sox won 5-3. Opening day at home, and the first regular season game played at Fenway Park, was April 20 also against the Highlanders. The Red Sox won that game 7-6.

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