Rommie Lewis debuted on April 28, 2010, playing for the Toronto Blue Jays at Rogers Centre; he played his final game on September 6, 2011, playing for the Toronto Blue Jays at Rogers Centre.
NFL player Thad Lewis played for Duke.
NFL player Isaiah Lewis played for Michigan.
NFL player Dion Lewis played for Pittsburgh.
NFL player Travis Lewis played for Oklahoma.
NFL player Kendrick Lewis played for Mississippi.
NFL player Marcedes Lewis played for UCLA.
NFL player Lance Lewis played for East Carolina.
NFL player Shaun Lewis played for Oklahoma State.
NFL player Patrick Lewis played for Texas A&M.
Lewis debuted on July 12, 1890, playing for the Buffalo Bisons at ; he played his final game on July 12, 1890, playing for the Buffalo Bisons at .
NFL player Keenan Lewis played for Oregon State.
NFL player Kapron Lewis-Moore played for Notre Dame.