Omir Santos debuted on September 5, 2008, playing for the Baltimore Orioles at Oriole Park at Camden Yards; he played his final game on April 9, 2013, playing for the Cleveland Indians at Progressive Field.
NFL player Cairo Santos played for Tulane.
Fautino De Los Santos debuted on June 4, 2011 and played his final game on April 23, 2012.
Luis de los Santos debuted on September 7, 1988 and played his final game on May 28, 1991.
Ramon de los Santos debuted on August 21, 1974 and played his final game on October 2, 1974.
Valerio De Los Santos debuted on July 31, 1998 and played his final game on August 2, 2008.
Ramon de los Santos debuted on August 21, 1974, playing for the Houston Astros at Astrodome; he played his final game on October 2, 1974, playing for the Houston Astros at Astrodome.
Angel Santos debuted on September 8, 2001, playing for the Boston Red Sox at Fenway Park II; he played his final game on September 28, 2003, playing for the Cleveland Indians at Jacobs Field.
Chad Santos debuted on July 16, 2006, playing for the San Francisco Giants at AT&T Park; he played his final game on July 20, 2006, playing for the San Francisco Giants at AT&T Park.
Francisco Santos debuted on June 18, 2003, playing for the San Francisco Giants at PacBell Park; he played his final game on July 3, 2003, playing for the San Francisco Giants at PacBell Park.
Victor Santos debuted on April 9, 2001, playing for the Detroit Tigers at Comerica Park; he played his final game on September 29, 2007, playing for the Baltimore Orioles at Oriole Park at Camden Yards.
Sergio Santos debuted on April 8, 2010, playing for the Chicago White Sox at U.S. Cellular Field; he played his final game on September 29, 2013, playing for the Toronto Blue Jays at Rogers Centre.
Valerio De Los Santos debuted on July 31, 1998, playing for the Milwaukee Brewers at County Stadium; he played his final game on August 2, 2008, playing for the Colorado Rockies at Coors Field.