John-Ford Griffin debuted on September 6, 2005, playing for the Toronto Blue Jays at Rogers Centre; he played his final game on September 30, 2007, playing for the Toronto Blue Jays at Rogers Centre.
NFL player John Griffin played for Massachusetts.
NFL player Michael Griffin played for Texas.
Thomas Griffin debuted on September 27, 1884, playing for the Milwaukee Brewers at ; he played his final game on October 11, 1884, playing for the Milwaukee Brewers at .
NFL player Ryan Broyles played for Oklahoma.
A. J. Griffin debuted on June 24, 2012, playing for the Oakland Athletics at O.co Coliseum; he played his final game on September 24, 2013, playing for the Oakland Athletics at O.co Coliseum.
Ivy Griffin debuted on September 9, 1919, playing for the Philadelphia Athletics at Shibe Park; he played his final game on August 28, 1921, playing for the Philadelphia Athletics at Shibe Park.
Tom Griffin debuted on April 10, 1969, playing for the Houston Astros at Astrodome; he played his final game on May 11, 1982, playing for the Pittsburgh Pirates at Three Rivers Stadium.
Alfredo Griffin debuted on September 4, 1976, playing for the Cleveland Indians at Cleveland Stadium; he played his final game on October 3, 1993, playing for the Toronto Blue Jays at Skydome.
Pat Griffin debuted on July 23, 1914, playing for the Cincinnati Reds at Crosley Field; he played his final game on July 23, 1914, playing for the Cincinnati Reds at Crosley Field.
Mike Griffin debuted on April 16, 1887, playing for the Baltimore Orioles at Oriole Park; he played his final game on October 15, 1898, playing for the Brooklyn Bridegrooms at Washington Park III.
Doug Griffin debuted on September 11, 1970, playing for the California Angels at Anaheim Stadium; he played his final game on June 2, 1977, playing for the Boston Red Sox at Fenway Park II.
Marty Griffin debuted on July 25, 1928, playing for the Boston Red Sox at Fenway Park I; he played his final game on September 7, 1928, playing for the Boston Red Sox at Fenway Park I.