Francisco Santos debuted on June 18, 2003, playing for the San Francisco Giants at PacBell Park; he played his final game on July 3, 2003, playing for the San Francisco Giants at PacBell Park.
Angel Santos debuted on September 8, 2001, playing for the Boston Red Sox at Fenway Park II; he played his final game on September 28, 2003, playing for the Cleveland Indians at Jacobs Field.
Francisco Cruceta debuted on September 21, 2004, playing for the Cleveland Indians at Jacobs Field; he played his final game on June 2, 2008, playing for the Detroit Tigers at Comerica Park.
Francisco Cordero debuted on August 2, 1999, playing for the Detroit Tigers at Tiger Stadium; he played his final game on August 1, 2012, playing for the Houston Astros at Minute Maid Park.
Frank Francisco debuted on May 14, 2004, playing for the Texas Rangers at The Ballpark at Arlington; he played his final game on September 29, 2013, playing for the New York Mets at Citi Field.
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Chad Santos debuted on July 16, 2006, playing for the San Francisco Giants at AT&T Park; he played his final game on July 20, 2006, playing for the San Francisco Giants at AT&T Park.
NFL player Cairo Santos played for Tulane.
Fautino De Los Santos debuted on June 4, 2011 and played his final game on April 23, 2012.
Luis de los Santos debuted on September 7, 1988 and played his final game on May 28, 1991.
Ramon de los Santos debuted on August 21, 1974 and played his final game on October 2, 1974.
Valerio De Los Santos debuted on July 31, 1998 and played his final game on August 2, 2008.
Francisco Barrios debuted on August 18, 1974 and played his final game on June 3, 1981.
Francisco Cabrera debuted on July 24, 1989 and played his final game on September 24, 1993.
Francisco Cervelli debuted on September 18, 2008 and played his final game on April 26, 2013.
Francisco Cordero debuted on August 2, 1999 and played his final game on August 1, 2012.
Francisco Cordova debuted on April 2, 1996 and played his final game on August 8, 2000.
Francisco Cruceta debuted on September 21, 2004 and played his final game on June 2, 2008.