Francisco Peguero debuted on August 25, 2012, playing for the San Francisco Giants at AT&T Park; he played his final game on September 29, 2013, playing for the San Francisco Giants at AT&T Park.
Jailen Peguero debuted on June 8, 2007, playing for the Arizona Diamondbacks at Chase Field; he played his final game on September 25, 2008, playing for the Arizona Diamondbacks at Chase Field.
Julio Peguero debuted on April 8, 1992, playing for the Philadelphia Phillies at Veterans Stadium; he played his final game on June 3, 1992, playing for the Philadelphia Phillies at Veterans Stadium.
Carlos Peguero debuted on April 19, 2011, playing for the Seattle Mariners at Safeco Field; he played his final game on April 27, 2013, playing for the Seattle Mariners at Safeco Field.
Francisco Barrios debuted on August 18, 1974 and played his final game on June 3, 1981.
Francisco Cabrera debuted on July 24, 1989 and played his final game on September 24, 1993.
Francisco Cervelli debuted on September 18, 2008 and played his final game on April 26, 2013.
Francisco Cordero debuted on August 2, 1999 and played his final game on August 1, 2012.
Francisco Cordova debuted on April 2, 1996 and played his final game on August 8, 2000.
Francisco Cruceta debuted on September 21, 2004 and played his final game on June 2, 2008.
Andre Rodgers was a cricket player who also played shortstop for the San Francisco Giants.
NBA player Francisco Garcia played for Louisville.
Jailen Peguero played in 7 games at pitcher for the Arizona Diamondbacks in 2008, starting in none of them. He played for a total of 28 outs, equivalent to 1.04 9-inning games. He made no putouts, had 3 assists, and committed no errors, equivalent to 0 errors per 9-inning game. He had one double play.