Bill Mack debuted on July 14, 1908, playing for the Chicago Cubs at West Side Park II; he played his final game on July 21, 1908, playing for the Chicago Cubs at West Side Park II.
Bill Upton debuted on April 13, 1954, playing for the Philadelphia Athletics at Connie Mack Stadium; he played his final game on May 3, 1954, playing for the Philadelphia Athletics at Connie Mack Stadium.
Mack Allison debuted on September 13, 1911 and played his final game on August 20, 1913.
Mack Burk debuted on May 25, 1956 and played his final game on June 22, 1958.
NBA player Shelvin Mack played for Butler.
NFL player Alex Mack played for California.
NFL player Elbert Mack played for Troy.
Bill Champion debuted on June 4, 1969, playing for the Philadelphia Phillies at Connie Mack Stadium; he played his final game on June 5, 1976, playing for the Milwaukee Brewers at County Stadium.
Bill Laxton debuted on September 15, 1970, playing for the Philadelphia Phillies at Connie Mack Stadium; he played his final game on September 19, 1977, playing for the Cleveland Indians at Cleveland Stadium.
Bill Nicholson debuted on June 13, 1936, playing for the Philadelphia Athletics at Shibe Park; he played his final game on September 19, 1953, playing for the Philadelphia Phillies at Connie Mack Stadium.
Mack Burk debuted on May 25, 1956, playing for the Philadelphia Phillies at Connie Mack Stadium; he played his final game on June 22, 1958, playing for the at .
Bill Harrington debuted on April 16, 1953, playing for the Philadelphia Athletics at Connie Mack Stadium; he played his final game on September 30, 1956, playing for the Kansas City Athletics at Municipal Stadium I.
NFL player Khalil Mack played for Buffalo.