Arthur Irwin debuted on May 1, 1880, playing for the Worcester Ruby Legs at Worcester Driving Park Grounds; he played his final game on June 22, 1894, playing for the Philadelphia Phillies at Philadelphia Baseball Grounds.
Walt Irwin debuted on April 24, 1921, playing for the at ; he played his final game on May 12, 1921, playing for the at .
NFL player Bronson Irwin played for Oklahoma.
John Irwin debuted on May 31, 1882, playing for the Worcester Ruby Legs at Worcester Driving Park Grounds; he played his final game on August 8, 1896, playing for the at .
Ed Irwin debuted on May 18, 1912, playing for the Detroit Tigers at Navin Field; he played his final game on May 18, 1912, playing for the Detroit Tigers at Navin Field.
Phil Irwin debuted on April 14, 2013, playing for the Pittsburgh Pirates at PNC Park; he played his final game on April 14, 2013, playing for the Pittsburgh Pirates at PNC Park.
NBA player Darrell Arthur played for Kansas.
NFL player Arthur Jones played for Syracuse.
NFL player Arthur Lynch played for Georgia.
NFL player Arthur Brown played for Kansas State.
NFL player Arthur Moats played for James Madison.
Charlie Irwin debuted on September 3, 1893, playing for the Chicago Colts at South Side Park I; he played his final game on October 3, 1902, playing for the Brooklyn Superbas at Washington Park III.
Bill Irwin debuted on August 30, 1886, playing for the Cincinnati Red Stockings at League Park I in Cincinnati; he played his final game on October 7, 1886, playing for the Cincinnati Red Stockings at League Park I in Cincinnati.