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Both the National League and American League record is 6 and has been achieved by 15 players.

The last American Leaguer to score 6 runs in a game was Joe Randa of the Kansas City Royals in a game against the Detroit Tigers on September 9, 2004. The Royals won that game, 26-5. The score at the end of 3 innings was 17-2. Randa had 6 hits in 7 at bats, 5 singles and 1 double.

The last National Leaguer to score 6 runs in a game was Shawn Green of the Los Angeles Dodgers in a game against the Milwaukee Brewers on May 23, 2002. The Dodgers won that game 16-3. Green has 6 hits in 6 at bats, 1 single, 1 double, and 4 home runs. He is one of only 15 players in MLB history to hit 4 home runs in one game.

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Q: What was the highest number of runs ever scored by a single player in a Major League Baseball game?
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