Villanova, North Carolina State
As of 2010 this has never happened. A number one seed has never lost to a 16 seed.
Louisville received their first ever number one ranking in basketball on march 16, 2009. Before that they have never been "ranked" number one in school history, not even during two previous championship seasons. They have been seed number one twice in the ncaa tournament: Once in 1983, and the other time coming as the overall number one seed in the 2009 mens basketball tournament.
Alabama has never won the NCAA Men's Basketball Championship. Their best showing was the Elite 8 in 2004.
Clemson University has never won the NCAA Men's Basketball Championship.
They have never won the championship.
they have never been to one in football and basketball.
They have never won the NCAA championship.
The lowest seed to ever win a NCAA Basketball title was Villanova, ranked seed #8. They won the tournament in 1985. Lower seeds have made it to the Final Four (George Mason and Louisiana State, ranked 11th, made it in 2006 and 1986 respectively) but never won. UCLA in 1980 was ranked 48th and made it to the championship game.
Penn State never won the national championship but they've made the final four several times.
Temple has never won a Men's NCAA basketball championship. They did reach the Final Four in 1956 and 1958.
Simply, YES. They are currently ranked 58th in the World by Fifa. They have never made it to the World Cup or European Championship.
Ohio State won the NCAA Men's Basketball Championship in 1960. Pitt has never won it.