Goose Goslin holds the record for most home runs hit at Yankee Stadium by an opposing player (32).
Mickey Mantle hit the most home runs at the old Yankee Stadium with 266.
Manny Ramirez did when he was a Red Sox player.
in 2009 New Yankee stadium
Most home runs in one stadium — 303 at Coors Field (Colorado Rockies) in 1999. I bet new Yankee Stadium will shatter that (110 to date!) THE AWNSER IS FENWAY PARK AND YANKEE STADIUM THEY ARE TIED
Mariano Rivera (230 at the original Yankee Stadium, which is not only the most at Yankee Stadium, but the most at ANY ballpark).
In 2009, Yankee Stadium yielded 237 home runs, which led the major leagues..