Peyton Manning with 28.
The quarterback who has thrown the most interceptions is Brett Favre, who through the 2010 season has thrown 336 career interceptions. The record for most interceptions by a defensive player in a career is held by Paul Krause, who intercepted 81 career passes.
Chicago Cardinals (now the Arizona Cardinals) quarterback Jim Hardy holds the dubious distinction of throwing a NFL Record 8 interceptions in a single game against the Philadelphia Eagles, September 24, 1950.
The career interception record is held by Paul Krause with 81 interceptions. The single-season record is held by Dick "Night Train" Lane with 14 interceptions. The most interceptions caught in a game is 4 by 20 players.
Rich Gannon of the Oakland Raiders threw 5 interceptions in Super Bowl XXXVII versus the Tamp Bay BUccaneers
Most Interceptions ThrownGeorge Blanda (Houston Oilers '62) threw the most interceptions in one season.
Check out the link attached about Jim Hardy he holds the nfl-record of 8 interceptions thrown in a single game. A long long time ago.
rod Wilson holds the nfl record for interceptions retuned for touchdowns with 12.
Rashean Mathis had 31 interceptions for Bethune-Cookman from 1999 to 2003.
Michael Vick of the Atlanta Falcons holds the NFL Quarterback single game rushing record with 173 yards from 10 attempts during a 2002 game vs the Vikings. Nealon Greene of the Edmonton Eskimos holds the CFL Quarterback single game rushing record with 180 yards in 14 carries versus the Saskatchewan Roughriders on July 19, 1999.
Paul Krause who played for the Minnesota Vikings. He had 81 interceptions for his career.
Former Bears quarterback Sid Luckman holds this record passing for 7 touchdowns on November 14th 1943.
Through Super Bowl XLIV, the QB with the most interceptions in a Super Bowl is Rich Gannon of the Oakland Raiders who threw 5 INTs in Super Bowl XXXVII against the Tampa Bay Buccaneers. Three of those interceptions were returned for touchdowns.
There are actually four different quarterbacks who hold that record. Brett Farve, Frank Filchock, Bobby Layne and Norm Van Brocklin all threw 6 interceptions in a single playoff game.