Since the beginning of interleague play:
Some of the 'old timers' that did it are:
Babe Ruth and Cy Williams both hit 41 home runs in 1923 to lead the Major Leagues.
Rogers Hornsby led the Major Leagues in home runs in 1925 with 39 home runs for St. Louis.
Mike Cameron is one of them
Andruw Jones hit 51 home runs in 2005, the most in both leagues.
Jimmie Foxx led the Major Leagues in 1933 with 48 home runs for Philadelphia.
Lou Gehrig led the Major Leagues with 49 home runs for the Yankees in 1934.
Lou Gehrig and Babe Ruth both of the New York Yankees led the Majors in 1931 with 46 home runs.
Jimmie Foxx (Philadelphia) and Hank Greenberg (Detroit) both tied for the lead for home runs in 1935 with 36 each.
Babe Ruth of the New York Yankees led the Major Leagues with 46 home runs in in 1924.
Babe Ruth of the New York Yankees led the Major Leagues with 47 home runs in in 1926.
Babe Ruth of the New York Yankees led the Major Leagues with 54 home runs in in 1928.
Babe Ruth of the New York Yankees led the Major Leagues with 46 home runs in in 1929.