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as of the 2010 season, the White Sox lead the all time record (since interleague play began) with 37 wins to the Cubs 35 wins.

The White Sox won the Interleague Series against the Cubs in 2010 by 4 games-to-2 so after the 2010 season, the White Sox lead in the series 41 Wins to 37 wins

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โˆ™ 2010-06-27 22:00:39
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Q: What is winloss record between Chicago Cubs vs Chicago White Sox?
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