as of the 2010 season, the White Sox lead the all time record (since interleague play began) with 37 wins to the Cubs 35 wins.
The White Sox won the Interleague Series against the Cubs in 2010 by 4 games-to-2 so after the 2010 season, the White Sox lead in the series 41 Wins to 37 wins
In 2006, the Chicago White Sox had a 90-72 record.
In 2008, the Chicago White Sox had an 89-74 record.
In 2012, the Chicago White Sox had an 85-67 record.
In 2000, the Chicago White Sox had a 95-67 record.
79-83
As of the start of play on July 21, 2007 the Chicago White Sox all time won loss record was 8343-8144.
In 2009, the Chicago White Sox played 162 games. They finished with a 79-83 record.
8,540 wins and 8,339 losses
99-63.
The team with the best regular season record to lose was the 1906 Chicago Cubs who went 116-36 and lost the World Series to the Chicago White Sox.
8,540 wins and 8,339 losses
Bobby Thigpen with 201 from 1986-1993.