What is the down side to beta alanine pro?

Answer 1

It is probable that the paraesthesia, a form of neuropathic pain, results from high peak blood-plasma concentrations of β-alanine since greater quantities, ingested in the form of the β-alanine / histidine (or methylhistidine) containing dipeptides (i.e. carnosine and anserine) in meat, do not cause the same symptoms. In this case the β-alanine absorption profile is flattened but sustained for a longer period of time,[5] whereas, the β-alanine samples in the studies were administered as gelatine capsules containing powder. This resulted in plasma concentrations rising rapidly, peaking within 30 to 45 minutes, and being eliminated after 90 to 120 minutes. The paraesthesia caused is no indication of efficacy since the published studies undertaken so far have utilised doses of 400 mg or 800 mg at a time to avoid the paraesthesia. Furthermore, excretion of β-alanine in urine accounted for 0.60%(+/-0.09), 1.50%(+/-0.40) and 3.64%(+/-0.47) of the administered doses of 10, 20, or 40 mg per kg body weight,[5] indicating greater losses occurring with increasing dosage.