Here's the all-time list as of the start of the 2008 season:
CAREER
RBI RBI
1 Todd Helton 1088
2 Larry Walker 848
3 Dante Bichette 826
4 Vinny Castilla 745
5 Andres Galarraga 579
6 Matt Holliday 395
7 Ellis Burks 337
8 Garrett Atkins 332
9 Neifi Perez 281
10 Brad Hawpe 256
11 Eric Young 227
12 Preston Wilson 217
13 Jeff Cirillo 198
14 Charlie Hayes 148
15 Walt Weiss 143
16 Juan Uribe 135
17 Jeff Reed 134
18 Mike Lansing 128
19 Terry Shumpert 124
20 Joe Girardi 120
21 Jay Payton 117
22 Clint Barmes 115
T23 Juan Pierre 110
T23 Jeromy Burnitz 110
T25 Greg Norton 108
T25 Charles Johnson 108
27 Jeffrey Hammonds 106
28 Troy Tulowitzki 105
T29 John Vander Wal 98
T29 Luis Gonzalez 98
T31 Yorvit Torrealba 90
T31 Todd Hollandsworth 90
33 Todd Zeile 87
34 Brent Mayne 84
35 Ben Petrick 82
36 Todd Walker 79
37 Mike Kingery 78
38 Quinton McCracken 76
39 Aaron Miles 75
40 Cory Sullivan 74
T41 Chris Stynes 73
T41 Ryan Spilborghs 73
43 Jason Bates 69
T44 Kirt Manwaring 67
T44 Jerald Clark 67
46 Brent Butler 60
T47 Todd Greene 58
T47 Jamey Carroll 58
T49 Kurt Abbott 56
T49 Kaz Matsui 56
T51 Royce Clayton 54
T51 Mark Sweeney 54
53 Angel Echevarria 52
54 Ron Belliard 50
55 Darryl Hamilton 49
56 J.D. Closser 48
T57 Tom Goodwin 47
T57 Jose Ortiz 47
T59 Bobby Estalella 46
T59 Nelson Liriano 46
61 Danny Sheaffer 44
T62 Howard Johnson 40
T62 Daryl Boston 40
T64 Roberto Mejia 38
T64 Dustan Mohr 38
T66 Jeff Baker 37
T66 Chris Iannetta 37
T68 Jayhawk Owens 36
T68 Jorge Piedra 36
70 Chris Jones 33
71 Gary Bennett 30
72 Choo Freeman 29
T73 Jeff Barry 28
T73 Henry Blanco 28
T75 Edgard Clemente 27
T75 Jose Hernandez 27
77 Freddie Benavides 26
78 Jason Jennings 25
T79 Trenidad Hubbard 24
T79 Danny Ardoin 24
T79 Alex Cole 24
T79 Willy Taveras 24
83 Ron Gant 22
T84 Darren Bragg 21
T84 Brian Bohanon 21
T84 Gabe Kapler 21
T84 Mike Hampton 21
T88 Benny Agbayani 19
T88 Pedro Astacio 19
T90 Mark Little 18
T90 Butch Huskey 18
T92 Alex Ochoa 17
T92 Ryan Shealy 17
T94 Desi Relaford 16
T94 Jimmy Tatum 16
96 Omar Quintanilla 15
97 Kit Pellow 14
T98 Greg Colbrunn 13
T98 Jason Smith 13
T98 Brian Hunter 13
T98 Scott Servais 13
T98 Jeff Francis 13
T98 Lenny Harris 13
T104 Jamey Wright 12
T104 Harvey Pulliam 12
T104 Sandy Alomar Jr. 12
T104 Adam Melhuse 12
T108 Miguel Ojeda 11
T108 John Thomson 11
T110 Denny Neagle 10
T110 Eli Marrero 10
T112 Pedro Castellano 9
T112 Sal Fasano 9
T112 Ian Stewart 9
T112 Darryl Kile 9
T112 Eric Anthony 9
T112 Shawn Chacon 9
T112 Brooks Kieschnick 9
T119 Jeff Salazar 8
T119 Bobby M. Jones 8
T119 Masato Yoshii 8
T119 Roger Bailey 8
T119 Eddy Garabito 8
T119 Rene Reyes 8
T119 Darren Oliver 8
T119 Jack Cust 8
T119 Derrick Gibson 8
T119 Gregg Zaun 8
T119 Dennis Stark 8
T119 Steve Decker 8
T131 Marvin Freeman 7
T131 Curt Leskanic 7
T131 Kevin Ritz 7
T131 Jacob Cruz 7
T131 Jorge Brito 7
T131 Chris Sexton 7
T131 Dale Murphy 7
T138 Aaron Cook 6
T138 Byung-Hyun Kim 6
T138 Armando Reynoso 6
T138 Curtis Goodwin 6
T138 Jay Gainer 6
T138 Bill Swift 6
T144 John Mabry 5
T144 Lance Painter 5
T144 Greg Vaughn 5
T144 Joe Kennedy 5
T144 Tony Womack 5
T144 Eric Byrnes 5
T144 Bubba Carpenter 5
T151 Jeff Manto 4
T151 J.R. Phillips 4
T151 Cliff Brumbaugh 4
T151 Ross Gload 4
T151 Mark Bellhorn 4
T151 Denny Hocking 4
T151 Willie Blair 4
T158 Rolando Arrojo 3
T158 Mario Encarnacion 3
T158 Greg Harris 3
T158 Mark Thompson 3
T158 Jeff Frye 3
T158 Aaron Ledesma 3
T158 Sun Woo Kim 3
T158 Chris Richard 3
T158 Mike Harkey 3
T158 Kent Bottenfield 3
T158 Michael Restovich 3
T158 Josh Fogg 3
T170 Chris Petersen 2
T170 Steve Finley 2
T170 Gabe White 2
T170 Dave Nied 2
T170 Shawn Estes 2
T170 Butch Henry 2
T170 Joe Koshansky 2
T170 Bryan Hickerson 2
T170 Frank Castillo 2
T170 Larry Bigbie 2
T170 Pablo Ozuna 2
T170 Milt Thompson 2
T170 Darnell Coles 2
T170 Joe Grahe 2
T170 Gary Wayne 2
T170 Jason Hirsh 2
T170 Marcos Carvajal 2
T170 Darren Holmes 2
T170 Andy Machado 2
T170 Alan Cockrell 2
T190 John Wasdin 1
T190 Andy Ashby 1
T190 Rene Gonzales 1
T190 Franklin Morales 1
T190 Jeff Fassero 1
T190 Mike Munoz 1
T190 Taylor Buchholz 1
T190 Steve Reed 1
T190 Alvin Colina 1
T190 Ramon Ortiz 1
T190 Tim Harikkala 1
T190 Jose Jimenez 1
T190 Jason Young 1
T190 Kimera Bartee 1
T190 Mike Kelly 1
T190 Elvis Pena 1
T190 Jason Romano 1
T190 Brian McRae 1
T190 John Burke 1
T190 Nelson Cruz 1
T190 Eric Wedge 1
T190 Terry Jones 1
T190 Bruce Ruffin 1
T190 Javier Lopez 1
T190 Andy Tracy 1
T190 Gerald Young 1
Bernie Williams holds the record for most career postseason RBIs with 80.
Career and Single Season RBI LeadersHank Wilson of the Chicago Cubs holds the major League record for RBIs in a single season with 191 hit in 1930. New York Yankees, Lou Gehrig holds the American League record for RBIs in a single season with 184 in 1931. Hank Aaron holds the Major League record for career RBIs with 2,297 and the National League record with 2,202. Babe Ruth is second in career RBIs with 2,218, and hold the American League career RBI record with 2,201.
Ted Williams had a career batting average of .344, 521 home runs and 1,839 RBIs
Lou Gehrig had 1,995 RBIs during his career.
Hank Aaron holds the MLB records for the most career runs batted in (RBI) (2,297), extra base hits (1,477), and total bases (6,856).
Bernie Williams has the most career postseason RBIs with 80.
Hank Wilson holds the record for most RBIs in a single season with 191, set in 1930.
Father Bob Boone had 4 career WS RBIs and son Aaron Boone had 2 career WS RBIs. Father Julian Javier had 7 career WS RBIs and son Stan Javier had 2 career WS RBIs.
Mickey Mantle ended his career with 1,509 RBIs.
Roberto Clemente had 240 career home runs.
Through the 2011 season, Albert Pujols of the St. Louis Cardinals has 1,329 career RBIs.
Click on the 'MLB Top 50 Lifetime RBIs' link on this page to see MLB's top 50 in career RBIs.