Peyton Manning with 28.
Most Interceptions ThrownGeorge Blanda (Houston Oilers '62) threw the most interceptions in one season.
The quarterback who has thrown the most interceptions is Brett Favre, who through the 2010 season has thrown 336 career interceptions. The record for most interceptions by a defensive player in a career is held by Paul Krause, who intercepted 81 career passes.
The quarterback that has the most interceptions is Brett Favre, he has 22 interceptions
Rich Gannon of the Oakland Raiders threw 5 interceptions in Super Bowl XXXVII versus the Tamp Bay BUccaneers
Rashean Mathis had 31 interceptions for Bethune-Cookman from 1999 to 2003.
rod Wilson holds the nfl record for interceptions retuned for touchdowns with 12.
Brette favre with most touchdowns thrown most passing yards most interceptions longest throw first quarterback to start his career with five interceptions to go to a probowl most mvp awards andmost wins