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I think Jim Bunning is the only pitcher to have won 100 games in American League (Tigers) and National League (Phillies/Dodgers).
Bunning won 118 in the AL and 106 in the NL. Others to do it are:

1) Cy Young - 290 in the NL and 221 in the AL.
2) Nolan Ryan - 135 in the NL and 189 in the AL.
3) Gaylord Perry - 139 in the AL and 175 in the NL.
4) Randy Johnson - 164 in the AL and 139 in the NL (through games played on September 22, 2009).
5) Ferguson Jenkins - 169 in the NL and 115 in the AL.
6) Dennis Martinez - 141 in the AL and 104 in the NL.
7) Pedro Martinez - 102 in the NL and 117 in the AL (through games played on September 22, 2009).
8) Kevin Brown - 102 in the AL and 109 in the NL.

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3y ago

Jim Bunning

Phil Niekro

Cy Young

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Q: Pitchers to win 100 games in both leagues?
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