3 times
The Mariners entered the American League in 1977, the same year as the Toronto Blue Jays.
Three times (1995, 1997, 2001)
In 1992, Scott Bradley played in 2 games for the Seattle Mariners, batting in all of them. He had 1 at bats, getting 0 hits, for a .000 batting average, with 0 runs batted in. He was walked 1 times. He struck out 1 times.
In 1999, Jeff Fassero played in 30 games for the Seattle Mariners, batting in 3 of them. He had 7 at bats, getting 0 hits, for a .000 batting average, with 0 runs batted in. He was walked 0 times. He struck out 5 times.
In 2004, Freddy Garcia played in 15 games for the Seattle Mariners, batting in 2 of them. He had 4 at bats, getting 0 hits, for a .000 batting average, with 0 runs batted in. He was walked 0 times. He struck out 3 times.
In 1997, Derek Lowe played in 12 games for the Seattle Mariners, batting in 2 of them. He had 2 at bats, getting 0 hits, for a .000 batting average, with 0 runs batted in. He was walked 0 times. He struck out 1 times.
In 1997, Brian Raabe played in 2 games for the Seattle Mariners, batting in all of them. He had 3 at bats, getting 0 hits, for a .000 batting average, with 0 runs batted in. He was walked 1 times. He struck out 2 times.
In 2013, Jeremy Bonderman played in 7 games for the Seattle Mariners, batting in all of them. He had 2 at bats, getting 0 hits, for a .000 batting average, with 0 runs batted in. He was walked 0 times. He struck out 2 times.
In 2013, Aaron Harang played in 22 games for the Seattle Mariners, batting in all of them. He had 4 at bats, getting 0 hits, for a .000 batting average, with 0 runs batted in. He was walked 0 times. He struck out 3 times.
In MLB, that was Jay Buhner of the Seattle Mariners with 175.
In 2006, Joe Borchard played in 6 games for the Seattle Mariners, batting in all of them. He had 9 at bats, getting 2 hits, for a .222 batting average, with 0 runs batted in. He was walked 0 times. He struck out 3 times. He hit only singles.
In 1998, Randy Johnson played in 23 games for the Seattle Mariners, batting in 2 of them. He had 7 at bats, getting 1 hits, for a .143 batting average, with 0 runs batted in. He was walked 0 times. He struck out 2 times. He hit only singles.