it depends are you thinking NFL or NCAA
The highest score in NCAA is 222-0 scored by the Georgia Tech Yellow Jackets
0-0 Raiders vs. Bills
Highest scoring Monday Night Football game took place on November 15, 2010. The Philadelphia Eagles won 59 to 28 against the Washingtion Redskins.
In the NCAA Division I tournament, the highest scoring game was Loyola Marymount over Michigan, 149-115, in the 2nd round in 1990.
wisconsin badgers scoring 121 against michigian in 1954
westerlo-genk 6-6 (belgian jupiler league) 99-00
Michigan vs Illinois 67-65 Michigan win
Morten Andersen with 2544 and is also the highest scoring player of any position ever
The most lopsided score was in 1916 when Georgia Tech defeated Cumberland by the score of 222-0. That is the highest score ever recorded.
Georgia Tech beat Cumberland (TN) 222-0 on October 7, 1916.