Twice in 2006, when Eli Manning played against his brother Peyton Manning.
No. They have played against each other in regular season games, but never in a Super Bowl.
The Only Quarterback Brothers to face each other are the Superbowl MVP's Eli and Payton Manning, back in 2006
Until one of the two brothers switches teams, they can only play in the Super Bowl, since Peyton plays for an AFC team (Colts) and Eli plays for an NFC team (Giants). Since they have never played against each other in the Super Bowl, they have never played in against each other in the playoffs.
Eli and Peyton have played against each other twice and Peyton's team has won twice, making Eli Manning's record against Peyton 0-2
The Charlton Brothers, Bobby and Jackie played against each other in the old first division. Bobby for Man Utd and Jackie for Leeds Utd.
There are a few brothers to play i the E.P.L against each other, they are Gary and Philip Neville. and Eitheu brothers wno play for Fulham and Manchester City,
twice ... and Peyton won both times.
No. As of February 2014, Eli and Peyton Manning have not played each other in a Super Bowl.
i belive Eli and payton are the only brothers who have played against each other as starting nfl qbs