Yes. They lost the 2004 ALCS to the Boston Red Sox.
They lost to the New York Yankees, 4-1
The Yankees are favored to take the 2010 ALCS.
The Phillies beat the Dodgers in the 2009 NLCS, and The Yankees beat the Angels in the 2009 ALCS.
New York Yankees
The Yankees finished first in the AL East in 1980 with a record of 103-59. They lost to the Kansas City Royals in the ALCS, 3 games to 0.
The Boston Red Sox beat the New York Yankees 4 games to 3 in the 2004 ALCS
The Yankees beat the Boston Red Sox 19-8 in game 3 of the 2004 ALCS.
Boston Red Sox
The Red Sox beat the Yankees 6-4 in 12 innings on October 17, game 4 of the 2004 ALCS
Red Sox pitcher Tim Wakefield gave up the home run to Aaron Boone in the bottom of the 11th inning in Game 7 that put the Yankees in the World Series.
The New York Yankees won 40 American League pennants.
The Mariners have played in three American League Championship Series: The closest they came to the World Series was Game 7 of the 2001 ALCS: In 2001, they lost to the Yankees 4 games to 3. In 2000, they lost to the Yankees 4 games to 2. In 1995, they lost to the Indians 4 games to 2.