Yes, they play 3 games there every year.
Craig Breslow debuted on July 23, 2005, playing for the San Diego Padres at Petco Park; he played his final game on September 29, 2013, playing for the Boston Red Sox at Fenway Park II.
Jeff Suppan debuted on July 17, 1995, playing for the Boston Red Sox at Fenway Park II; he played his final game on May 28, 2012, playing for the San Diego Padres at Petco Park.
Will Venable debuted on August 29, 2008, playing for the San Diego Padres at Petco Park; he played his final game on September 29, 2013, playing for the San Diego Padres at Petco Park.
Matt Antonelli debuted on September 1, 2008, playing for the San Diego Padres at Petco Park; he played his final game on September 28, 2008, playing for the San Diego Padres at Petco Park.
Kyle Blanks debuted on June 19, 2009, playing for the San Diego Padres at Petco Park; he played his final game on September 25, 2013, playing for the San Diego Padres at Petco Park.
Brad Boxberger debuted on June 10, 2012, playing for the San Diego Padres at Petco Park; he played his final game on September 27, 2013, playing for the San Diego Padres at Petco Park.
Brad Brach debuted on August 31, 2011, playing for the San Diego Padres at Petco Park; he played his final game on September 27, 2013, playing for the San Diego Padres at Petco Park.
Everth Cabrera debuted on April 8, 2009, playing for the San Diego Padres at Petco Park; he played his final game on August 4, 2013, playing for the San Diego Padres at Petco Park.
Cesar Carrillo debuted on August 13, 2009, playing for the San Diego Padres at Petco Park; he played his final game on August 23, 2009, playing for the San Diego Padres at Petco Park.
Callix Crabbe debuted on April 3, 2008, playing for the San Diego Padres at Petco Park; he played his final game on May 8, 2008, playing for the San Diego Padres at Petco Park.
James Darnell debuted on August 9, 2011, playing for the San Diego Padres at Petco Park; he played his final game on May 17, 2012, playing for the San Diego Padres at Petco Park.
Jaff Decker debuted on June 20, 2013, playing for the San Diego Padres at Petco Park; he played his final game on August 25, 2013, playing for the San Diego Padres at Petco Park.