Yes
From 1979 - 2010, 54 no 1 seeds have made the final four. That's 42.2%
Since seeding began in 1979, 19 of the champions were #1 seeds. 2008 is the only year in which all four #1 seeds made it to the Final Four. (This is as through the 2012 tournament.)
2008
Yes. Going in to the 2013 Final Four, the record for #1 seeds vs. #4 seeds in the NCAA men's basketball tournament is 42-21 in favor of the #1 seeds. This includes two such games in the 2013 tournament: #4 Michigan over #1 Kansas and #4Syracuse over #1 Indiana.
2005
The number one seeds in the 1980 NCAA basketball tournament were DePaul, LSU, Kentucky and Syracuse. Louisville was a number two seed. Click on the '1980 NCAA Basketball Seedings' link on this page to see an entire listing of the seedings.
Yes, the 2008 NCAA Men's Basketball tournament is the first one where all four #1 seeds made the Final Four.
12
The first four 11 seeds are significant in the NCAA basketball tournament selection process because they compete in play-in games to earn a spot in the main tournament bracket. These games give lower-seeded teams a chance to prove themselves and potentially advance further in the tournament.
Last time no #1s made the FF was 2006. UCLA-2 FLA -3 LSU -4 George Mason - 11. Fla beat UCLA in the final.
As of now, there are 65 teams in the tournament. Two teams (generally considered to be the worst in the tournament) play an "opening round" game. The winner gets the fourth 16 seed in the first round of the tournament.
From 1979 (when seeds were first used) through 2013, the NCAA men's basketball tournament Final Fours that have had at least one #1 seed is 91.4%. Only three times has the Final Four notincluded at least one #1 seed: 1980, 2006 and 2011. The titles in those years were won by a #2 seed, #3 seed and #3 seed respectively.For the record, there has been only one year when all four #1 seeds made it to the Final Four. This was in 2008.