No, Pete Rose's final MLB game was August 17, 1986.
Through the 2017 regular season, the two teams have played 711 games. The Houston Astros have 378 wins and 333 losses against the Chicago Cubs.
The Houston Astros finished the 1981 season with a record of 61-49. (strike shortened season)
The Houston Astros finished the 1970 season with a record of 79-83.
The Houston Astros finished the 1971 season with a record of 79-83
The Houston Astros finished the 1972 season with a record of 84-69.
The Houston Astros finished the 1974 season with a record of 81-81.
The Houston Astros finished the 1975 season with a record of 64-97.
The Houston Astros finished the 1976 season with a record of 80-82.
The Houston Astros finished the 1977 season with a record of 81-81.
The Houston Astros finished the 1978 season with a record of 74-88.
The Houston Astros finished the 1979 season with a record of 89-73.
As of the 2014 season, the Houston Astros have 5 switch hitters.