The 2012 NFL season is just starting, let's give it a couple of months first. Somebody will be back to edit this answer soon.
Yes. On September 23, 2007, the San Francisco 49ers lost to the Steelers 37-16.
The Steelers and San Francisco 49ers have met 20 times in their history. The 49ers lead the series 11-9.
The Steelers and 49ers met one time on December 19th during their history.It was in 2011, the 49ers defeated the Steelers 20-3 in San Francisco.
The NFL on NBC - 1965 Pittsburgh Steelers vs- San Francisco 49ers was released on: USA: 15 December 1973
From 2003-2012, the Steelers played the San Francisco 49ers three times. The 49ers have a 2-1 record.
Steelers (6), Cowboys (5), 49ers (5).
Through the 2011 season, the San Francisco 49ers have an all-time record of 11-9 versus the Steelers.
On December 19, 2011, the Steelers - 49ers game will be televised on ESPN at 8:30PM.
The 49ers lead the all-time series 10-9 versus the Steelers.
As of the 2008 season, The Dallas Cowboys, San Francisco 49ers, and the Pittsburgh Steelers all have 5 Super Bowl wins.Addition: As of writing this addition, the Pittsburgh Steelers have six.
NFL Monday Night Football - 1970 Pittsburgh Steelers vs. San Francisco 49ers - 9.13 was released on: USA: 27 November 1978
NFL Monday Night Football - 1970 Pittsburgh Steelers at San Francisco 49ers 42-16 was released on: USA: 19 December 2011