Here's some names, but depends on what defines 'big 4' and 'major' these days:
Owen - Liverpool, Madrid, Utd
Petit - Chelsea, Arsenal, Barcalona
Diarra- Arsenal, Chelsea, Madrid
Zenden- Chelsea, Barcelona, Liverpool
Anelka- Chelsea, Liverpool, Madrid
Hughes- Utd, Barcelona, Chelsea
others may include
Pennant- Liverpool, Arsenal, Real Zaragoza
Torres - Liverpool, Chelsea, Athletico Madrid
Benayoun - Chelsea, Arsenal, Liverpool, Racing de Santander
The major players in the Spanish American War were Spain, the United States, and to a lesser extent Cuba and the Philippines. It was caused by the United States intervening in the Cuban war for independence.
To many to count
In order for players to be playable players in "MLB 08 The Show," they must have played at least 1 game in the previous Major League Baseball season and they cannot be 1 of the players that are known as "replacement players" meaning players who played during the 1995 season while there was a Baseball strike ongoing, this is because the replacement players are banned from entering into the Players' Association which means they cannot be in any games that are under license with Major League Baseball and the Players' Association.